Gliomas are the most common form
of malignant brain tumor in adults
and have generally poor clinical outcomes.
Patients with the most aggressive
form of glioma, glioblastoma multiforme
(GBM), have a low 5-year survival rate ( 1).
Progress has been made in characterizing the
genetic lesions and cells of origin in GBM,
both of which may contribute to disease
pathogenesis. On page 1080 in this issue,
Friedmann-Morvinski et al. ( 2) show that differentiated
neuronal cells and glial cells in the
mouse brain can revert to less mature states
upon acquiring these genetic lesions. Thus,