given the many potential intracellular targets, and large DNA nanostructures are believed to have difficulty penetrating biological membranes. The display of amphiphilic molecules or cell-penetrating peptides on the surface of nanobots might facilitate tissue penetration and
cellular uptake.
Another concern is that DNA-origami containers, which can require nearly 200 unique oligonucleotides, are structurally more complicated than liposomes and many other drug carriers. For large-scale production, it may be necessary to minimize the number of constituent strands and reduce the complexity of the design, perhaps to even a single DNA strand10.
Despite these challenges, it is conceivable that DNA nanobots could one day be used to
influence the gene expression or metabolic pathways of target cells11. As with any
drug-delivery strategy, improved understanding
given the many potential intracellular targets, and large DNA nanostructures are believed to have difficulty penetrating biological membranes. The display of amphiphilic molecules or cell-penetrating peptides on the surface of nanobots might facilitate tissue penetration and
cellular uptake.
Another concern is that DNA-origami containers, which can require nearly 200 unique oligonucleotides, are structurally more complicated than liposomes and many other drug carriers. For large-scale production, it may be necessary to minimize the number of constituent strands and reduce the complexity of the design, perhaps to even a single DNA strand10.
Despite these challenges, it is conceivable that DNA nanobots could one day be used to
influence the gene expression or metabolic pathways of target cells11. As with any
drug-delivery strategy, improved understanding
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