格列波脲是通过调节糖代谢，来促进全身组织对葡萄糖的摄取和利用，并抑制糖

格列波脲是通过调节糖代谢，来促进全身组织对葡萄糖的摄取和利用，并抑制糖原的分解和糖原异生，因此，具有降低血糖的作用。

格列波脲是通过共价修饰增强磷酸二酯酶活性、降低cAMP水平、升高cGMP浓度，从而使糖原合成酶活性增加、磷酸化酶活性降低，加速糖原合成、抑制糖原分解。通过激活丙酮酸脱氢酶磷酸酶而使丙酮酸脱氢酶激活，加速丙酮酸氧化为乙酰辅酶A，加快糖的有氧氧化。通过抑制PEP羧激酶的合成以及减少糖异生的原料，抑制糖异生。

結果 (英文) 1:

Glibornuride by regulating glucose metabolism, to promote General Organization for glucose uptake and utilization, and to inhibit the breakdown of glycogen and gluconeogenesis, therefore, has a blood sugar-lowering effect.Glibornuride is enhanced by the Covalent modification of Phosphodiesterase activity, reducing cAMP levels, increased cGMP concentration, so that the increase in glycogen synthase activity, activity of phosphorylase decreased, and accelerating glycogen synthesis, inhibition of glycogenolysis. Through activation of Pyruvate dehydrogenase phosphatase activation of Pyruvate dehydrogenase, accelerated oxidation of Pyruvate to acetyl CoA, expedite the aerobic oxidation of sugar. By inhibiting the synthesis of PEP carboxykinase, and materials to reduce gluconeogenesis, inhibiting gluconeogenesis.

結果 (英文) 3:

Glibornuride is through the regulation of glucose metabolism to promote the uptake of glucose in body tissues and utilization, and the inhibition of glycogen decomposition and gluconeogenesis, it has the blood glucose lowering effect.

glibornuride is by covalent modification enhanced phosphodiesterase activity and decrease of cAMP level, increase in cGMP concentration, so that the glycogen synthetase activity was increased and phosphorylase activity decreased, accelerated glycogen synthesis, inhibition of glycogenolysis. Activation of pyruvate dehydrogenase by activation of pyruvate dehydrogenase phosphatase, accelerate the oxidation of pyruvate to acetyl coenzyme A, accelerate the aerobic oxidation of sugar. By inhibiting the synthesis of PEP and reducing the raw materials of sugar,Inhibition of sugar.